CAS NO: | 135897-06-2 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
生物活性 | SB-218078 is a potent, selective, ATP-competitive and cell-permeablecheckpoint kinase 1 (Chk1)inhibitor that inhibitsChk1phosphorylation of cdc25C with anIC50of 15 nM. SB-218078 is less potently inhibitsCdc2(IC50of 250 nM) andPKC(IC50of 1000 nM). SB-218078 causesapoptosisby DNA damage and cell cycle arrest[1][2][3]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | SB-218078 (2.5-5 μM; 18 hours; HeLa cells) treatment abrogates G2 cell cycle arrest caused by either γ-irradiation or a topoisomerase I Topotecan inhibition[1]. Cell Cycle Analysis[1]
Cell Cytotoxicity Assay[1]
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体内研究 (In Vivo) | SB-218078 (5 mg/kg; intraperitoneal injection; for 16 hours; C57/Bl6 mice) treatment could promote a strong increase of γ-H2AX and apoptosis throughout the lymphoma, while having no effect on a healthy spleen in Myc-induced lymphomas mouse model[2].
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分子量 | 393.39 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C24H15N3O3 | ||||||||||||||||
CAS 号 | 135897-06-2 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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