BMT-090605

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BMT-090605

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1551403-51-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

BMT-090605 是一种有效的选择性连接蛋白-2 相关激酶 1(AAK1)抑制剂，IC₅₀值为 0.6 nM。BMT-090605 显示抗伤害活性。BMT-090605 抑制 BMP-2 诱导蛋白激酶 (BIKE) 和细胞周期蛋白 G 相关激酶 GAK，IC₅₀值分别为 45 nM 和 60 nM。BMT-090605 可用于神经性疼痛的研究。

生物活性

BMT-090605 is a potent, selectivethe adapter protein-2 associated kinase 1 (AAK1)inhibitor with anIC₅₀value of 0.6 nM. BMT-090605 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) andCyclin G-associated kinase (GAK)withIC₅₀values of 45 nM and 60 nM, respectively. BMT-090605 can be used for the research of neuropathic pain^[1].

IC₅₀& Target

IC50: 0.6 nM (AAK1); 45 nM (BIKE); 60 nM (GAK)^[1]

体外研究
(In Vitro)

BMT-090605 shows AAK1inhibitory activity with an IC₅₀of 0.63 nM^[1].
BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC₅₀values of 45 nM and 60 nM, respectively^[1].

体内研究
(In Vivo)

BMT-090605 (intrathecal; 0.3-3 μg/rat) causes antinociception by inhibiting AAK1 in the spinal cord^[1].

Animal Model:	Male Sprague-Dawley rats (chronic constriction injury (CCI) model)^[1]
Dosage:	0.3-3 μg/rat
Administration:	Intrathecal
Result:	Caused a dose-dependent reduction in thermal hyperalgesia.

分子量

364.44

Formula

C₂₁H₂₄N₄O₂

CAS 号

1551403-51-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.