CAS NO: | 154-93-8 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
生物活性 | Carmustine is an antitumor chemotherapeutic agent, which works byakylating DNA and RNA. | ||||||||||||||||
IC50& Target | DNA Alkylator[1] | ||||||||||||||||
体外研究 (In Vitro) | Carmustine is an antitumor chemotherapeutic agent. Carmustine (8, 80, and 800 μM) decreases N-acetyltransferase (NAT) activities for 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) in rat glial tumor cytosol and intact cells. In rat glial tumor cells, the DNA-AF adduct increases, and carmustine decreases the formation of DNA-AF adduct[1]. | ||||||||||||||||
体内研究 (In Vivo) | Carmustine (BCNU; 25 mg/kg, i.p.) causes higher levels of the rhe ratio of liver weight to body weight and plasma conjugated bilirubin, and lower biliary flow, oxidised glutation levels (GSSG) and reduced glutation (GSH)/GSSG values compared with control rats[2]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 214.05 | ||||||||||||||||
性状 | <30℃ Solid,>30℃ Liquid | ||||||||||||||||
Formula | C5H9Cl2N3O2 | ||||||||||||||||
CAS 号 | 154-93-8 | ||||||||||||||||
中文名称 | 卡莫司汀;卡氮芥;亚硝脲氮芥;氯乙亚硝脲;卡莫斯汀;卡莫司丁 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | -20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 100 mg/mL(467.18 mM;Need ultrasonic) DMSO : ≥ 35 mg/mL(163.51 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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