CAS NO: | 158382-37-7 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Canfosfamide (TLK-286, TER286) is a glutathione analogue prodrug that is activated by glutathione S-transferase P1-1 and inducesapoptosis. Canfosfamide also inhibits the catalytic kinase activity of DNA-dependent protein kinase (DNA-PK). Canfosfamide produces an anticancer alkylating agent and a glutathione derivative after activation. Canfosfamide can be used to research malignancies[1][2][3]. | ||||||||
IC50& Target | IC50: ~1 μM (DNA-PK)[3] | ||||||||
体外研究 (In Vitro) | Canfosfamide (TLK-28) inhibit the catalytic kinase activity of purified DNA-dependent protein kinase (DNA-PK) with an IC50value of ~1 μM, but causes minimal direct damage to DNA[2]. Cell Proliferation Assay[3]
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体内研究 (In Vivo) | Canfosfamide (TER286) exhibits more effective antitumor effect in more frequent administration[3].
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Clinical Trial | |||||||||
分子量 | 787.47 | ||||||||
Formula | C26H40Cl4N5O10PS | ||||||||
CAS 号 | 158382-37-7 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |