CAS NO: | 154447-35-5 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | NU 7026 (LY293646) is a novel specificDNA-PKinhibitor withIC50of 0.23 μM, also inhibitsPI3KwithIC50of 13 μM. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | NU7026 (10 μM) potentiates ionizing radiation (IR) cytotoxicity [potentiation factor at 90% cell kill (PF90)=1.51±0.04] in exponentially growing DNA-PK proficient but not deficient cells[1]. NU7026 synergistically sensitizes I83 cells to Chlorambucil (CLB) 3.5-fold[2].NU7026, a novel inhibitor of the DNA repair enzyme DNA-dependent protein kinase (DNA-PK). At a dose of 10 μM, which is nontoxic to cellsper se, a minimum NU7026 exposure of 4 h in combination with 3 Gy radiation is required for a significant radiosensitisation effect in CH1 human ovarian cancer cells[3]. | ||||||||||||||||
体内研究 (In Vivo) | NU7026, a novel inhibitor of the DNA repair enzyme DNA-dependent protein kinase (DNA-PK). Following intravenous administration to mice at 5 mg/kg, NU7026 underwent rapid plasma clearance (0.108 L/h) and this is largely attributed to extensive metabolism. Bioavailability following interperitoneal (i.p.) and p.o. administration at 20 mg/kg is 20 and 15%, respectively[3]. | ||||||||||||||||
分子量 | 281.31 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C17H15NO3 | ||||||||||||||||
CAS 号 | 154447-35-5 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 2.5 mg/mL(8.89 mM;Need ultrasonic) 配制储备液
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