CAS NO: | 1879887-96-3 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | LTURM34 is a specificDNA-PKinhibitor (IC50=34 nM). LTURM34 exhibits 170-fold selectivity forDNA-PKoverPI3K. LTURM34 shows potent antiproliferative activity in a wide range of tumor cell lines[1]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | LTURM34 shows potent inhibition of DNA-PK with excellent selectivity over the Class I PI3K isoforms. The IC50s are 5.8 and 8.5 μM for PI3K β and δ, respectively. LTURM34 is more consistently active against the selected cell lines (11 of 16), but at best shows 54% inhibition against the HOP-92 non-small cell lung cancer line[1]. | ||||||||||||||||
分子量 | 414.48 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C24H18N2O3S | ||||||||||||||||
CAS 号 | 1879887-96-3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 65 mg/mL(156.82 mM;Need ultrasonic) 配制储备液
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