CAS NO: | 1943733-16-1 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | YU238259 is an inhibitor of homology-dependent DNA repair (HDR), used forcancerresearch. | ||||||||||||||||
IC50& Target | HDR[1] | ||||||||||||||||
体外研究 (In Vitro) | YU238259 is an inhibitor of homology-dependent DNA repair, with no effect on PARP activity. YU238259 shows cytotoxicity in BRCA2-deficient cells, with a low LD50of 8.5 μM. YU238259 (0-5 μM) causes a potent, dose-dependent decrease in HDR efficiency in U2OS DR-GFP or U2OS EJ5-GFP cells, but with no effect on NHEJ frequency. YU238259 (0-10 μM) exhibits synthetic lethality with loss of frequently mutated tumor suppressors, and shows synergism with radiotherapy (IR) and DNA-damaging chemotherapy that is potentiated by BRCA2 loss[1]. | ||||||||||||||||
体内研究 (In Vivo) | YU238259 (3 mg/kg, i.p.) inhibits the growth of BRCA2-deficient tumor xenografts in nude mice[1]. | ||||||||||||||||
分子量 | 459.95 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C22H22ClN3O4S | ||||||||||||||||
CAS 号 | 1943733-16-1 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 110 mg/mL(239.16 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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