Briciclib

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Briciclib

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

865783-99-9

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
1mg	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品名称

ON 014185

产品介绍

Briciclib (ON 014185) 是一种 ON 013100 衍生物，具有靶作用于eIF4E对抗固体肿瘤的潜力。

生物活性

Briciclib (ON 014185) is a derivative of ON 013100, and has the potential in targetingeIF4Efor solid cancers.

IC₅₀& Target

eIF4

体外研究
(In Vitro)

Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI₅₀s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours^[1].

Clinical Trial

分子量

474.42

性状

Solid

Formula

C₁₉H₂₃O₁₀PS

CAS 号

865783-99-9

中文名称

布瑞西利

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 31 mg/mL(65.34 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.1078 mL	10.5392 mL	21.0784 mL
5 mM	0.4216 mL	2.1078 mL	4.2157 mL
10 mM	0.2108 mL	1.0539 mL	2.1078 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。