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Pyridostatin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pyridostatin图片
CAS NO:1085412-37-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
RR82
产品介绍
Pyridostatin (RR82) 是一种高选择性的G-quadruplex DNA稳定剂 (Kd=490 nM)。Pyridostatin 通过诱导复制和转录依赖的 DNA 损伤促进人类癌细胞生长停滞。Pyridostatin 靶向原癌基因 Src。Pyridostatin 降低人乳腺癌细胞 SRC 蛋白水平和 SRC 依赖的细胞运动。
生物活性

Pyridostatin (RR82) is aG-quadruplexDNAstabilizing agent (Kd=490 nM). Pyridostatin promotes growth arrest in humancancercells by inducing replication- and transcription-dependent DNA damage. Pyridostatin targets the proto-oncogeneSrc. Pyridostatin reducedSRCprotein levels and SRC-dependent cellular motility in human breastcancercells[1][2].

IC50& Target

Kd: 490 nM (G-quadruplexe)[1]

体外研究
(In Vitro)

Pyridostatin (RR82) (10 μM; 48 hours) induces cell cycle arrest[1].
Pyridostatin is a very selective G-quadruplex DNA-binding small molecule designed to form a complex with and stabilize G-quadruplex structure. Pyridostatin causes neurite retraction, synaptic loss, and dose-dependent neuronal death. In cultured primary neurons, Pyridostatin induces the formation of DNA DSBs. Remarkably, Pyridostatin (1-5 μM, overnight) downregulates the BRCA1 protein, a protein that guards and repairs the neuronal genome, at the transcriptional level[3].

Cell Viability Assay[1]

Cell Line:Over 60 different cancer cell lines
Concentration:10 μM
Incubation Time:48 hours
Result:Predominantly accumulated in the G2 phase of the cell cycle over 60 different cancer cell lines.
分子量

596.64

Formula

C31H32N8O5

CAS 号

1085412-37-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.