包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | G4/HDAC-IN-1 (compound a6) is aG4/HDACdual-targeting compound. G4/HDAC-IN-1 inhibits intracellularHDACactivity with anIC50value of 1.1 μM, and induces G4 formation. G4/HDAC-IN-1 inhibits TNBC proliferation and tumor growth in TNBC xenograft model. G4/HDAC-IN-1 can be used for the research ofcancer[1]. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | G4/HDAC-IN-1 (0-10 μM; 1.5 h) shows HDAC inhibitory activity with an IC50of 1.9 μM by determining nuclear extract and exhibits inhibitory activity on intracellular HDAC activity in MDA-MB-231 cells with an IC50value of 1.1 μM[1].G4/HDAC-IN-1 (0-50 μM) shows G4 binding activity with an IC50of 0.4 μM[1].G4/HDAC-IN-1 (0-10 μM; 1.5 h) inhibits HDAC1, HDAC8, HDAC4, HDAC6 and HDAC11 activities with IC50s of 1.26, 0.03, 2.64, 0.65 and 1.38 μM, respectively[1].G4/HDAC-IN-1 (0-50 μM) binds with Pu22, HRAS and HTG21 sequences with KDvalues of 1.8, 3.6 and >10 μM, respectively[1].G4/HDAC-IN-1 (1.25-5.0 μM; 48 h) dose-dependently increases DNA G4 level[1].G4/HDAC-IN-1 (0-50 μM; overnight) inhibits cytotoxic activities of TNBC cell lines[1]. Western Blot Analysis[1]
Cell Cytotoxicity Assay[1]
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体内研究 (In Vivo) | G4/HDAC-IN-1 (2.5 mg/kg; i.p. once daily for 31 days) shows antitumor activity[1].
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分子量 | 698.27 | ||||||||||||||||
Formula | C36H49ClFN7O4 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |