CAS NO: | 2309172-48-1 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | LDN-192960 hydrochloride is an inhibitor ofHaspinandDual-specificity Tyrosine-regulated Kinase 2 (DYRK2)withIC50s of 10 nM and 48 nM, respectively[1]. | ||||||||||||||||
IC50& Target | IC50: 10 nM (Haspin); 48 nM (DYRK2)[1] | ||||||||||||||||
体外研究 (In Vitro) | LDN-192960 hydrochloride (10 μM) is selective and inhibits ten of the other kinases by ≥90%, with only five being potently inhibited (IC50<1 μm), including clk1 (ic50=0.21 μM), DYRK1A (IC50= 0.10 μM), DYRK2 (IC50=2 nM), DYRK3 (IC50=19 nM) and PIM1 (IC50=0.72 μM)[1].LDN-0192960 hydrochloride (0-5 μM; 2 hours) demonstrates that the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells overexpressing Haspin with an EC50of 1.17 μM[2].LDN-0192960 hydrochloride (0-1 μM; 1 hour incubation in the presence of nocodazole and MG132) demonstrates the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells synchronized in mitosis with an EC50of 0.02 μM[2]. | ||||||||||||||||
分子量 | 401.35 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C18H22Cl2N2O2S | ||||||||||||||||
CAS 号 | 2309172-48-1 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 7.14 mg/mL(17.79 mM;Need ultrasonic) 配制储备液
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