Etrolizumab

立即咨询

Etrolizumab

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1044758-60-2

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议
50mg	电议

产品名称

rhuMAb Beta7
RG7413
PRO145223

产品介绍

Etrolizumab (rhuMAb Beta7) 是一种肠道选择性抗-β7整合素单克隆抗体。Etrolizuma b是针对 α4β7 和 αEβ7 整合素的 β7 亚基的特异性靶向药物。Etrolizumab 可用于炎症性肠病 (IBD) 的研究。

生物活性

Etrolizumab (rhuMAb Beta7) is a gut-selective, anti-β7integrinmonoclonal antibody. Etrolizumab is specific targeting of the β7 subunit ofα4β7and αEβ7 integrins withK_ivalues of 18 nM and 1800 pM for Humanα4β7and Human αEβ7-293, respectively. Etrolizumab can be used in research of inflammatory bowel disease (IBD)^[1]^[2].

IC₅₀& Target^[1]

α4β7

αEβ7

体外研究
(In Vitro)

Etrolizumab (rhuMAb Beta7) binds the β7 subunit of both α4β7 and αEβ7 integrins with high affinity, with K_dvalues of 18 nM, 1800 pM, 181 pM, 116 pM, 57 pM, 31.7 pM, and 25.7 pM for Human α4β7, Human αEβ7-293, Mouse α4β7-38C13, Human α4β7-293, Rabbit PBLs, Human PBLs, and Cyno PBLs, respectively^[1].
Etrolizumab (RPMI 8866 cells and αEβ7-293 cells) blocks the interaction of α4β7 with its cognate ligands MAdCAM-1 and VCAM-1 with IC₅₀values of 0.075 and 0.089 nM, respectively, and blocks the interaction between αEβ7 and its ligand E-cadherin with an IC₅₀value of 3.96 nM^[1].

体内研究
(In Vivo)

Etrolizumab (rhuMAb Beta7; 5 mg/kg; i.v.; once; normal female BALB/c mice) decreases β7 integrins on T lymphocytes^[2].
Etrolizumab (200 μg (100 μL); i.p.; once) inhibits lymphocyte homing in the CD45RB^highT cell-reconstituted SCID mouse model of colitis^[2].

Animal Model:	Normal female BALB/c mice (17-21 g)^[2]
Dosage:	5 mg/kg
Administration:	Intravenous injection; once
Result:	Had 98.3% of intraepithelial CD8⁺T-cell β7 integrin receptors and 90.0% of intraepithelial CD4⁺T-cell β7 integrin receptors after 24 h.

Animal Model:	SCID mouse model of colitis^[2]
Dosage:	200 μg (100 μL)
Administration:	Intraperitoneal injection; once
Result:	Blocked lymphocyte recruitment and homing to the inflamed colon.

Clinical Trial

性状

Liquid

CAS 号

1044758-60-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.