CAS NO: | 1025967-78-5 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Lifitegrast (SAR 1118) is a potentintegrinantagonist. Lifitegrast blocks the binding ofintercellular adhesion molecule 1 (ICAM-1)to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment toICAM-1with anIC50of 2.98 nM. Lifitegrast can be used for researching dry eye disease[1]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Lifitegrast (SAR 1118) inhibits T cell-mediated inflammation by blocking the binding of two important cell surface proteins (lymphocyte function-associated antigen 1 and intercellular adhesion molecule 1), thus lessening overall inflammatory responses[1]. | ||||||||||||||||
体内研究 (In Vivo) | Lifitegrast (SAR 1118), has potent anti-inflammatory activity on corneal inflammation induced by antibiotic-killedP. aeruginosaandS. aureusin the presence of a silicone hydrogel lens with the optimal application being a 1% solution applied either 2 or 3 times prior[2]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 615.48 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C29H24Cl2N2O7S | ||||||||||||||||
CAS 号 | 1025967-78-5 | ||||||||||||||||
中文名称 | 立他司特 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 29 mg/mL(47.12 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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