CAS NO: | 1246529-32-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
2mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | MPI-0479605 is a potent and selective ATP-competitive inhibitor ofMps1, with anIC50of 1.8 nM. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | MPI-0479605 is a potent and selective ATP-competitive inhibitor of Mps1, with an IC50of 1.8 nM. MPI-0479605 (0.1-10 μM) reduces cell viability of HCT-116 cells in a dose-dependent manner. MPI-0479605 shows severe defects in the ability to align chromosomes at the metaphase plate, but causes complete cytokinesis[1]. | ||||||||||||||||
体内研究 (In Vivo) | MPI-0479605 (30 mg/kg daily or 150 mg/kg every fourth day (Q4D), i.p.) inhibits tumor growth by 49% and 74 % in HCT-116 xenografts. However, MPI-0479605 does not show inhibitory activity via daily dosing on the Colo-205 xenografts, and dosing every four days causes 63% tumor growth inhibition (TGI)[1]. | ||||||||||||||||
分子量 | 407.51 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C22H29N7O | ||||||||||||||||
CAS 号 | 1246529-32-7 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 11 mg/mL(26.99 mM;Need ultrasonic and warming) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |