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MPI-0479605
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MPI-0479605图片
CAS NO:1246529-32-7
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
2mg电议
5mg电议
10mg电议
50mg电议
100mg电议
200mg电议

产品介绍
MPI-0479605 是一种有效的,选择性的,ATP 竞争性的Mps1抑制剂,IC50值为 1.8 nM。
生物活性

MPI-0479605 is a potent and selective ATP-competitive inhibitor ofMps1, with anIC50of 1.8 nM.

IC50& Target[1]

Mps1

1.8 nM (IC50)

ALK

0.26 μM (IC50)

B-RAF

3.2 μM (IC50)

ERK2

3.9 μM (IC50)

FAK1

2.7 μM (IC50)

FER

0.59 μM (IC50)

FLT3

0.08 μM (IC50)

INSR

0.38 μM (IC50)

JNK1

0.11 μM (IC50)

PLK4

3.3 μM (IC50)

STK33

1.1 μM (IC50)

体外研究
(In Vitro)

MPI-0479605 is a potent and selective ATP-competitive inhibitor of Mps1, with an IC50of 1.8 nM. MPI-0479605 (0.1-10 μM) reduces cell viability of HCT-116 cells in a dose-dependent manner. MPI-0479605 shows severe defects in the ability to align chromosomes at the metaphase plate, but causes complete cytokinesis[1].

体内研究
(In Vivo)

MPI-0479605 (30 mg/kg daily or 150 mg/kg every fourth day (Q4D), i.p.) inhibits tumor growth by 49% and 74 % in HCT-116 xenografts. However, MPI-0479605 does not show inhibitory activity via daily dosing on the Colo-205 xenografts, and dosing every four days causes 63% tumor growth inhibition (TGI)[1].

分子量

407.51

性状

Solid

Formula

C22H29N7O

CAS 号

1246529-32-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 11 mg/mL(26.99 mM;Need ultrasonic and warming)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.4539 mL12.2696 mL24.5393 mL
5 mM0.4908 mL2.4539 mL4.9079 mL
10 mM0.2454 mL1.2270 mL2.4539 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。