CAS NO: | 1578245-44-9 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50of 11 nM and 63 nM forMPS1(1 mM ATP) and P-MPS1, respectively. BOS-172722 also has potential for the study of various forms of breastcancer[1]. | ||||||||||||||||
IC50& Target | 2 nM (MPS1)[1]. | ||||||||||||||||
体外研究 (In Vitro) | BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50of 2 nM. BOS-172722 also has potential for the treatment of various forms of breast cancer[1]. | ||||||||||||||||
体内研究 (In Vivo) | BOS-172722 shows excellent PK in mouse, rat, and dog[1].
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Clinical Trial | |||||||||||||||||
分子量 | 446.55 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C24H30N8O | ||||||||||||||||
CAS 号 | 1578245-44-9 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: 1M HCl : 65 mg/mL(145.56 mM;ultrasonic and adjust pH to 2 with HCl) DMSO : 5 mg/mL(11.20 mM;Need ultrasonic) 配制储备液
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