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TC-Mps1-12
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TC-Mps1-12图片
CAS NO:1206170-62-8
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
TC-Mps1-12 是一种高效、选择性的Mps1抑制剂,其IC50值为 6.4 nM。
生物活性

TC-Mps1-12 is a potent and selectivemonopolar spindle 1 (Mps1)inhibitor, with anIC50of 6.4 nM[1].

IC50& Target

IC50: 6.4 nM (Mps1)[1]

体外研究
(In Vitro)

TC-Mps1-12 inhibits the growth of pMps1 cell lines with IC50 values of 131 nM in autophosphorylation assay[1].
TC-Mps1-12 (72 hours) inhibits the growth of cells in a dose-dependent manner and with an IC50values of 0.84 μM[1].

Cell Viability Assay[1]

Cell Line:549 cells
Concentration:
Incubation Time:72 hours
Result:Inhibited the growth of cells in a dose-dependent manner and with an IC50values of 0.84 μM.
体内研究
(In Vivo)

TC-Mps1-12 (25-100 mg/kg; p.o.; daily; for 19 days) inhibits the growth of A549 cells in a dose-dependent manner in vivo. At a dose of 100 mg/kg, TC-Mps1-12 exhibits 47% tumor growth inhibition without body weight loss[1].
TC-Mps1-12 shows good PK properties with a Cmax of 3542 ng/mL and AUC of 6604 ng h/mL at an oral dose of 25 mg/kg[1].

Animal Model:A549 mouse xenograft model[1]
Dosage:25 mg/kg, 50 mg/kg, 100 mg/kg
Administration:Oral administration; once daily; for 19 days
Result:Inhibited the growth of A549 cells in a dose-dependent manner.
Animal Model:A549 mouse xenograft model (pharmacokinetic )[1]
Dosage:25 mg/kg
Administration:Oral administration
Result:Cmax= 3542 ng/mL, AUC = 6604 ng h/mL
分子量

324.38

性状

Solid

Formula

C17H20N6O

CAS 号

1206170-62-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month