包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | AZ13705339 hemihydrate is a highly potent and selectivePAK1inhibitor withIC50s of 0.33 nM and 59 nM forPAK1and pPAK1, respectively. AZ13705339 hemihydrate has binding affinities toPAK1andPAK2, withKds of 0.28 nM and 0.32 nM, respectively. AZ13705339 hemihydrate can be used in the research of cancers[1]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | AZ13705339 (1 μM) hemihydrate inhibits αIgM-controlled adhesion and not PMA-induced adhesion in Namalwa cells[2]. | ||||||||||||||||
体内研究 (In Vivo) | AZ13705339 hemihydrate (100 mg/kg, P.O.) has moderate clearance and oral Cmaxof 7.7 μM in rats[1]. | ||||||||||||||||
分子量 | 638.77 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C33H36FN7O3S.1/2H2O | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(156.55 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |