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UCL 2077
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
UCL 2077图片
CAS NO:918311-87-2
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
UCL 2077 是一种选择性慢后超极化 (sAHP) 通道阻滞剂（在培养的海马神经元中 IC50 =500 nM），对超极化后的 Ca2+ 通道、动作电位、输入电阻和介质影响最小。
Cas No.918311-87-2
化学名1,1,1-triphenyl-N-(pyridin-3-ylmethyl)methanamine
Canonical SMILESC1(C(C2=CC=CC=C2)(C3=CC=CC=C3)NCC4=CC=CN=C4)=CC=CC=C1
分子式C25H22N2
分子量350.46
溶解度<17.52mg/ml in DMSO;<8.76mg/ml in ethanol
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

UCL 2077 is a selective slow-afterhyperpolarization (sAHP) channel blocker (IC50 = 500 nM in hippocampal neurons in culture), having minimal effects on Ca2+ channels, action potentials, input resistance and the medium after hyperpolarization[1]. UCL 2077 is also a subtype-selective blocker of the epilepsy associated KCNQ channels[2].

References:
[1]. Shah MM, et al. Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077). Mol Pharmacol. 2006 Nov;70(5):1494-502.
[2]. Soh H, et al. The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels. Mol Pharmacol. 2010 Dec;78(6):1088-95.