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WAY 213613
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
WAY 213613图片
CAS NO:868359-05-1
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
WAY 213613 是一种有效的选择性人 EAAT2 抑制剂。
Cas No.868359-05-1
别名N-[4-(2-溴-4,5-二氟苯氧基)苯基]-L-天冬酰胺
化学名(S)-2-amino-4-((4-(2-bromo-4,5-difluorophenoxy)phenyl)amino)-4-oxobutanoic acid
Canonical SMILESBrC(C(OC1=CC=C(C=C1)NC(C[C@@H](C(O)=O)N)=O)=C2)=CC(F)=C2F
分子式C16H13BrF2N2O4
分子量415.19
溶解度<41.51mg/ml in DMSO;<41.51mg/ml in 1eq. NaOH
储存条件Desiccate at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

WAY-213613 is a potent, selective nonsubstrate reuptake inhibitor of GLT-1/EAAT2 with IC50 of 85 nM EAAT2. It displays 59- and 44-fold selectivity over EAAT1 and EAAT3 (IC50s are 5 and 3.8 μM, respectively). WAY-213613 shows no activity at ionotropic and metabotropic glutamate receptors. It is a potential tool for the elucidation of EAAT2 function[1][2].

References:
[1]. Dunlop J, et al. Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2. Mol Pharmacol. 2005 Oct;68(4):974-82. Epub 2005 Jul 13.
[2]. Simmons DA, et al. A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. PLoS One. 2014 Aug 25;9(8):e102136.