CAS NO: | 1115-70-4 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) inhibits themitochondrial respiratory chainin the liver, leading to activation ofAMPK, enhancinginsulinsensitivity for type 2 diabetes research. Metformin hydrochloride triggersautophagy[1]. | ||||||||||||||||
IC50& Target[2] |
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体外研究 (In Vitro) | Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) inhibits proliferation of ESCs in a concentration-dependent manner. The IC50is 2.45 mM for A-ESCs and 7.87 mM for N-ESCs. Metformin shows pronounced effects on activation of AMPK signaling in A-ESCs from secretory phase than in cells from proliferative phase[2]. | ||||||||||||||||
体内研究 (In Vivo) | Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride; 100 mg/kg, p.o.) alone, and metformin (25, 50, 100 mg/kg) with NSC 37745 groups attenuates myocyte necrosis through histopathological analysis[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 165.62 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C4H12ClN5 | ||||||||||||||||
CAS 号 | 1115-70-4 | ||||||||||||||||
中文名称 | 盐酸二甲双胍;甲福明;降糖片 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : ≥ 100 mg/mL(603.79 mM) DMSO : ≥ 1.7 mg/mL(10.26 mM) *"≥" means soluble, but saturation unknown. 配制储备液
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以下溶剂前显示的百
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