CAS NO: | 1214265-58-3 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | WZ4003 is the first potent and highly specificNUAK kinaseinhibitor withIC50of 20 nM/100 nM forNUAK1(ARK5)/NUAK2, without significant inhibition on other 139 kinases. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | WZ4003 (3-10 μM) markedly suppresses NUAK1-mediated MYPT1 phosphorylation, in HEK-293 cells expressing wild-type NUAK1. Moreover, WZ4003 (10 μM) inhibits MYPT1 Ser445 phosphorylation as well as cell migration, invasion and proliferation to a similar extent as knock out in MEFs or knock down in U2OS cells of NUAK1[1]. WZ4003 also exhibits a high, specific affinity to the L858R/T790M mutant EGFR, while a significantly reduced cellular IC50against T790M containing Ba/F3 cells[2]. | ||||||||||||||||
分子量 | 496.99 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C25H29ClN6O3 | ||||||||||||||||
CAS 号 | 1214265-58-3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 33.33 mg/mL(67.06 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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