ZIKV-IN-3

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ZIKV-IN-3

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

947699-46-9

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

ZIKV-IN-3 (compound 5a) 是一种穿心莲内酯衍生物, 是有效的 ZIKV NS5 甲基转移酶 (MTase) 抑制剂，其IC₅₀值为 18.34 μM。ZIKV-IN-3 抑制 ZIKV 的复制和感染。ZIKV-IN-3 可用于寨卡病毒 (ZIKV) 的研究。

生物活性

ZIKV-IN-3 (compound 5a), an andrographolide derivatives, is a potent ZIKV NS5methyl transferase (MTase)inhibitor with anIC₅₀value of 18.34 μM. ZIKV-IN-3 inhibits ZIKV replication andinfection. ZIKV-IN-3 can be used in research of Zika virus (ZIKV)^[1].

IC₅₀& Target

IC50: 18.34 μM (MTase)^[1]

体外研究
(In Vitro)

ZIKV-IN-2 (compound 5a; 0.08-50 μM) inhibits ZIKV-induced plaque formation with an EC₅₀value of 0.76 μM and has anti-ZIKV effect with EC₅₀values of 0.48, 0.37, and 0.45 μM for Vero, Huh7 and A549 cells, respectively^[1].
ZIKV-IN-2 (0.08-50 μM; 48 h) inhibits the expression of ZIKV E protein with an EC₅₀value of 0.38 μM and inhibits ZIKV replication and infection^[1].
ZIKV-IN-2 (0.08-50 μM; 96 h) has low cytotoxicity in Vero, Huh7 and A549 cells^[1]. Vero, Huh7 and A549 cells^[1].

Cell Viability Assay^[1]

Cell Line:	Vero, Huh7 and A549 cells
Concentration:	0.08, 0.4, 2, 10, and 50 μM
Incubation Time:	96 hours
Result:	Exhibited low cytotoxicities to Vero cells, Huh7 cells and A549 cells with CC₅₀>200 μM to all three cell lines.

Western Blot Analysis^[1]

Cell Line:	Vero cells
Concentration:	0.08, 0.4, 2, 10, and 50 μM
Incubation Time:	48 hours
Result:	Inhibited the expression of ZIKV E protein in a dose-dependent manner.

分子量

587.75

Formula

C₃₉H₄₁NO₄

CAS 号

947699-46-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.