CAS NO: | 499-44-5 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Hinokitiol is a component of essential oils isolated fromChymacyparis obtusa, reducesNrf2expression, and decreasesDNMT1and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities. | ||||||||||||||||
IC50& Target[1][2] |
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体外研究 (In Vitro) | In U87MG and T98G glioma cell lines, hinokitiol demonstrates a dose-dependent decrease in viability, with IC50values of 316.5 ± 35.5 and 152.5 ± 25.3 μM, respectively. Hinokitiol represses ALDH activity and self-renewal ability in glioma stem cells, and inhibits in vitro oncogenicity. Hinokitiol also reduces Nrf2 expression in glioma stem cells in a dose-dependent manner[1]. Hinokitiol (0-100 μM) inhibits colon cancer cell growth in a dose- and time-dependent manner. Hinokitiol (5, 10 μM) decreases DNMT1 and UHRF1 mRNA and protein expression, and increases TET1 expression via enhancement of 5hmC level in HCT-116 cells. Furthermore, hinokitiol reduces methylation status and restores mRNA expression ofMGMT,CHST10, andBTG4genes[2]. | ||||||||||||||||
分子量 | 164.20 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C10H12O2 | ||||||||||||||||
CAS 号 | 499-44-5 | ||||||||||||||||
中文名称 | 桧木醇;扁柏酚;扁柏醇;日柏醇 | ||||||||||||||||
结构分类 |
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来源 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(609.01 mM;Need ultrasonic) H2O : 0.67 mg/mL(4.08 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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