CAS NO: | 192441-08-0 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Lomeguatrib is a O6-methylguanine-DNA methyltransferase (MGMT) inhibitor, withIC50s of 9 nM in cell-free assay and ~6 nM in MCF-7 cells. | ||||||||||||||||
IC50& Target[1][2] |
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体外研究 (In Vitro) | Lomeguatrib (Compound 10) is a O6-methylguanine methyltransferase (MGMT) inhibitor, with an IC50of 9 nM in cell-free assay[1]and ~6 nM in MCF-7 cells. Lomeguatrib (10 μM) substantially increases the growth inhibitory effects of temozolomide in MCF-7 cells (D60=10 μM with Lomeguatrib vs 400 μM without)[2]. | ||||||||||||||||
体内研究 (In Vivo) | Lomeguatrib (20 mg/kg i.p.) completely inactivates MGMT within 2 h, but shows no significant effect on tumor growth in MCF-7 xenografts[2]. | ||||||||||||||||
分子量 | 326.17 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C10H8BrN5OS | ||||||||||||||||
CAS 号 | 192441-08-0 | ||||||||||||||||
中文名称 | 罗米鲁曲 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 56 mg/mL(171.69 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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