CAS NO: | 328968-36-1 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | C646 is a selective and competitivehistone acetyltransferasep300inhibitor withKiof 400 nM, and is less potent for other acetyltransferases[1]. | ||||||||||||||||
IC50& Target | Ki: 400 nM (histone acetyltransferase p300) | ||||||||||||||||
体外研究 (In Vitro) | C646 is a linear competitive inhibitor of p300 versus acetyl-CoA with a Ki of 400 nM. C646 shows a noncompetitive pattern of p300 inhibition versus H4-15 peptide substrate. C646 treatment reduces histone H3 and H4 acetylation levels and abrogates TSA-induced acetylation in cells. C646 has a more potent effect on cell growth than Lys-CoA-Tat does[1]. C646 enhances mitotic catastrophe after IR and suppresses phosphorylation of CHK1 after IRin A549 cells[2]. C646 attenuates the increased acetylation of GATA1 and the increased transcriptional activity of GATA1 induced by EDAG[3]. | ||||||||||||||||
体内研究 (In Vivo) | Suppression of P300 by c646 (intraperitoneally injected, 30 nmol/g/d for 2 weeks) dramatically reduces the level of blood glucose in db/db mice[4].
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分子量 | 445.42 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C24H19N3O6 | ||||||||||||||||
CAS 号 | 328968-36-1 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 16.67 mg/mL(37.43 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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