CAS NO: | 1997321-20-6 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | GNE-064 (compound 5) is a selective, orally active and highly soluble inhibitor ofSMARCA4,SMARCA2andPBRM1bromodomains 5. GNE-064 inhibits SMARCA4 with anIC50of 0.035 μM and inhibits SMARCA2 with anEC50of 0.10 μM. GNE-064 possessKds with 0.01, 0.016, 0.018 and 0.049 μM for SMARCA4, SMARCA2, PBRM1 bromodomains 5 and PBRM1 bromodomains 2, repectively. GNE-064 can be used as a chemical probe for the research of drug synthesis[1]. | ||||||||||||||||
IC50& Target | IC50: 0.035 μM (SMARCA4)[1] | ||||||||||||||||
体外研究 (In Vitro) | GNE-064 (0-0.5 μM; 1 h) inhibits SMARCA2 in ZsGreen-SMARCA2 BD-expressing U2OS cells[1]. Cell Viability Assay[1]
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体内研究 (In Vivo) | GNE-064 (compound 5) (0.5 and 1.0 mg/kg; i.v. and p.o. once ) exibits ideal pharmacokinetics value in female CD-1 mice[1].
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分子量 | 327.38 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C17H21N5O2 | ||||||||||||||||
CAS 号 | 1997321-20-6 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 125 mg/mL(381.82 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |