CAS NO: | 1950634-92-0 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | dBET6 is a highly potent, selective and cell-permeablePROTACconnected by ligands forCereblonandBET, with anIC50of 14 nM, and has antitumor activity. | ||||||||||||||||
IC50& Target | IC50: 14 nM (BET)[1] | ||||||||||||||||
体外研究 (In Vitro) | dBET6 is a highly potent, selective and cell-permeable degrader of BET with an IC50of 14 nM. dBET6 (100 nM) exhibits antitumor activity against T cell acute lymphoblastic leukemia (T-ALL) lines via degradation of BRD4[1]. | ||||||||||||||||
体内研究 (In Vivo) | dBET6 (7.5 mg/kg, p.o., BID) reduces the leukemic burden in a disseminated mouse model of T-ALL[1]. | ||||||||||||||||
分子量 | 841.37 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C42H45ClN8O7S | ||||||||||||||||
CAS 号 | 1950634-92-0 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 50 mg/mL(59.43 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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