CAS NO: | 2259641-46-6 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | DS-9300 is a potent, orally active, selectiveEP300/CBP HATinhibitor with anIC50value of 28 nM. DS-9300 has anticancer activity and can be used in prostatecancerdisease research[1]. | ||||||||||||||||||
体外研究 (In Vitro) | DS-9300 inhibits the growth of prostate cancer cell lines with the IC50values of 0.6, 6.5, 3.4 and 287.2 nM for VCaP, 22Rv1, LNCaP and PC3 cells, respectively, indicating that it could effectively inhibit the growth of prostate cancer cell lines by inhibiting histone acetylation and down-regulating PSA expression[1]. | ||||||||||||||||||
体内研究 (In Vivo) | DS-9300 (p.o., 0.3-3 mg/kg, once daily, 33days) shows dose-dependent antitumor activity with 39%, 74% and 109% tumor growth inhibition at 0.3, 1 and 3 mg/kg, respectively, and no significant toxic effects in Castrated VCaP xenograft mouse model[1].
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分子量 | 501.50 | ||||||||||||||||||
Formula | C25H26F3N5O3 | ||||||||||||||||||
CAS 号 | 2259641-46-6 | ||||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |