CAS NO: | 158093-65-3 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | PU139 is a potent pan-histone acetyltransferase(HAT)inhibitor. PU139 blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB (cAMP response element-binding) protein (CBP) and p300 withIC50s of 8.39, 9.74, 2.49 and 5.35 μM, respectively[1][2]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | PU139 inhibits cell growth with GI50s of<60 μm (a431, a549, a2780, hepg2, sw480, u-87 mg, hct116 and sk-n-sh mcf7 cells)[1]. | ||||||||||||||||
体内研究 (In Vivo) | PU139 (25 mg/kg; i.p.) synergizes with Doxorubicin used as a prototypic chemotherapeutic drug in growth inhibition[1].
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分子量 | 246.26 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C12H7FN2OS | ||||||||||||||||
CAS 号 | 158093-65-3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 12.5 mg/mL(50.76 mM;ultrasonic and warming and heat to 60℃) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |