CAS NO: | 1373422-53-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | GSK-J1 is a potent inhibitor ofH3K27me3/me2-demethylases JMJD3/KDM6BandUTX/KDM6A, withIC50of 60 nM towards KDM6B. | ||||||||||||||||
IC50& Target | IC50: 60 nM (KDM6B)[2] | ||||||||||||||||
体外研究 (In Vitro) | GSK-J1 is selective for H3K27 demethylases of the KDM6 subfamily and specifically binds to endogenous JMJD3. GSK-J1 inhibits TNF-α production by human primary macrophages in an H3K27-dependent manner[1]. GSK-J1 inhibits the demethylase activity of KDM5C with 8.5-fold increased potency compared with that of KDM5B at 1 mM α-ketoglutarate, with IC50of 11 μM and 94 μM, respectively[3]. | ||||||||||||||||
分子量 | 389.45 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C22H23N5O2 | ||||||||||||||||
CAS 号 | 1373422-53-7 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 50 mg/mL(128.39 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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