您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > DMP 543
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
DMP 543
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
DMP 543图片
CAS NO:160588-45-4
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
DMP 543 (XR-543) 是一种 KV7 通道阻滞剂，也可作为一种有效的神经递质释放增强剂。
Cas No.160588-45-4
别名10,10-双[(2-氟-4-吡啶基)甲基]-9(10H)-蒽酮,XR-543
化学名10,10-bis((2-fluoropyridin-4-yl)methyl)anthracen-9(10H)-one
Canonical SMILESFC1=NC=CC(CC(C2=CC=CC=C23)(CC4=CC(F)=NC=C4)C5=CC=CC=C5C3=O)=C1
分子式C26H18F2N2O
分子量412.44
溶解度<41.24mg/ml in DMSO;<20.62mg/ml in ethanol
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DMP-543 (XR-543) is a KV7 channel blocker, also acts as a potent neurotransmitter release enhancer[1][2].

DMP-543 enhances [3H]ACh release from rat brain slices, with an EC50 of 700 nM[2].

References:
[1]. Ipavec V, et al. KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus. Pharmacol Res. 2011 Oct;64(4):397-409.
[2]. Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 May;285(2):724-30.