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Revusiran
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1438322-82-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
ALN-TTRSC
产品介绍
Revusiran (ALN-TTRSC) 是第一代短干扰 RNA,针对转甲状腺素蛋白 (TTR) mRNA。Revusiran 可用于转甲状腺素蛋白 (TTR) 介导的淀粉样变性研究。
生物活性

Revusiran (ALN-TTRSC) is a 1st-generation short interfering RNA, which directed againsttransthyretin (TTR)mRNA. Revusiran can be used fortransthyretin(TTR)-mediated amyloidosis research[1].

体外研究
(In Vitro)

Revusiran is a chemically synthesized double-stranded siRNA that is covalently linked at the 3′-end of its sense strand to a ligand containing three GalNAc residues. Revusiran is a 1st-generation short interfering RNA targeting transthyretin conjugated to an N-acetylgalactosamine ligand to facilitate delivery to hepatocytes via uptake by the asialoglycoprotein receptors[1].

体内研究
(In Vivo)

There are no effects on cardiovascular or respiratory function in monkeys after single doses of up to 100 mg/kg. No neurological effects weare noted in monkeys in repeat-dose studies up to 300 mg/kg. Revusiran is well tolerated in repeat-dose mouse (weekly doses) and rat and monkey (five daily doses followed by weekly doses) toxicity studies[1].

Clinical Trial
CAS 号

1438322-82-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.