Gadolinium chloride

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Gadolinium chloride

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

10138-52-0

包装与价格：

包装	价格(元)
25mg	电议
50mg	电议
100mg	电议
500mg	电议
1 g	电议
5 g	电议

产品名称

GdCl3

产品介绍

Gadolinium chloride 是一种特殊的钙敏感受体 (CaSR) 激动剂。Gadolinium chloride 可用于心血管疾病的研究。

生物活性

Gadolinium chloride is a specific calcium-sensing receptor (CaSR) agonist. Gadolinium chloride can be used for the research ofcardiovascular disease^[1].

IC₅₀& Target

CaSR^[1]

体外研究
(In Vitro)

Gadolinium chloride (30 μM; 15 minutes; H9c2 cells) results in increased Bax expression and caspase-3 activation, and decreased Bcl-2 expression in CsA-induced cells^[1].
In vitro, GdCl3, a CaSR agonist, has been shown to promote the apoptosis of myocardial cells, which increases ERK1/2 phosphorylation and activates caspase-3^[1].

Western Blot Analysis^[1]

Cell Line:	H9c2 cells
Concentration:	30 μM
Incubation Time:	15 minutes
Result:	Resulted in increased Bax expression and caspase-3 activation, and decreased Bcl-2 expression in CsA-induced cells.

分子量

263.61

性状

Solid

Formula

Cl₃Gd

CAS 号

10138-52-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

1M HCl : 100 mg/mL(379.35 mM;ultrasonic and adjust pH to 1 with HCl)

DMSO :< 1 mg/mL (ultrasonic;warming;heat to 60℃)(insoluble or slightly soluble)

H₂O :< 0.1 mg/mL (ultrasonic;warming;heat to 60℃)(insoluble)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	3.7935 mL	18.9674 mL	37.9348 mL
5 mM	0.7587 mL	3.7935 mL	7.5870 mL
10 mM	0.3793 mL	1.8967 mL	3.7935 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。