Cagrilintide acetate

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议

产品介绍

Cagrilintide acetate 是一种非选择性的AMYR/CTR激动剂和长效酰化淀粉酶类似物。Cagrilintide acetate 以剂量依赖的方式导致食物摄入减少和体重明显下降。Cagrilintide acetate 可用于肥胖症的研究。

生物活性

Cagrilintide acetate is a non-selectiveAMYR/CTRagonist and long-acting acylated amylase analogue. Cagrilintide acetate causes a reduction in food intake and significant weight loss in a dose-dependent manner. Cagrilintide acetate can be used in obesity studies^[1]^[2]^[3].

IC₅₀& Target

AMYR, CTR^[1]^[2]^[3].

体内研究
(In Vivo)

Cagrilintide acetate (compound 23) (0.1, 1, 3, 10, 30 nmol/kg; s.c.single) reduces food intake in the rat^[1].
Cagrilintide acetate (10 nmol/kg; i.v. or s.c.; single) shows good pharmacokinetic parameters^[1].

Animal Model:	Sprague Dawley male rats (12-week-old; ~400 g)^[1]
Dosage:	0.1, 1, 3, 10, 30 nmol/kg
Administration:	Subcutaneous injection; single
Result:	Reduced food intake in the rat for several days at doses in the range of 1-10 nmol/kg.

Animal Model:	Sprague Dawley male rats (12-week-old; ~400 g)^[1]
Dosage:	10 nmol/kg
Administration:	Intravenous injection or subcutaneous injection; single
Result:	Showed good pharmacokinetic parameters with T_1/2of 20, 27 h for i.v. and s.c., respectively.

Clinical Trial

Sequence Shortening

{Ggu}KCNTATCATQRLAEFLRHSSNNFGPILPPTNVGSNTP (Disulfide bridge:Cys3-Cys8)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.