| CAS NO: | 117399-94-7 |
| 包装 | 价格(元) |
| 500 μg | 电议 |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 生物活性 | Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptorsETAandETB[1]. | ||||||||||||
| IC50& Target |
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| 体外研究 (In Vitro) | Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. It acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion[1]. | ||||||||||||
| 分子量 | 2491.90 | ||||||||||||
| 性状 | Solid | ||||||||||||
| Formula | C109H159N25O32S5 | ||||||||||||
| CAS 号 | 117399-94-7 | ||||||||||||
| Sequence | Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridge: Cys1-Cys15, Cys3-Cys11) | ||||||||||||
| Sequence Shortening | CSCSSLMDKECVYFCHLDIIW (Disulfide bridge: Cys1-Cys15, Cys3-Cys11) | ||||||||||||
| 中文名称 | 内皮缩血管肽 1 (猪,人) | ||||||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| 储存方式 |
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| 溶解性数据 | In Vitro: H2O : 1.82 mg/mL(0.73 mM;ultrasonic and adjust pH to 3 with HCl) |
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