TUG-469

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TUG-469

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1236109-67-3

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品介绍

TUG-469 是选择性的游离脂肪酸受体 1 (FFA1/GPR40) 激动剂，EC₅₀值为 19 nM。TUG-469 对 FFA1 的选择性是 FFA4 的 200 倍。TUG-469 显著改善糖尿病早期小鼠的糖耐量。TUG-469 可用于糖尿病的研究。

生物活性

TUG-469 is a selectivefree fatty acid receptor1 (FFA1/GPR40) agonist with anEC₅₀value of 19 nM. TUG-469 is >200-fold selective for FFA1 over FFA4. TUG-469 significantly improves glucose tolerance in pre-diabetic mice. TUG-469 can be used for the research of diabetes^[1]^[2].

体外研究
(In Vitro)

TUG-469 (0-10 μM) shows efficacy to hFFA1 with a pEC₅₀value of 7.73^[1].
TUG-469 (10 μM) increases the insulin secretion under 10 mM glucose stimulation^[1].
TUG-469 (0-100 μM) is >200-fold selective for FFA1 over FFA4 with EC₅₀values of 19 nM and 4.4 μM for FFA1 and FFA4, respectively^[2].
TUG-469 (5 μM; 30 min) significantly increases insulin secretion of INS-1 cells with the presence of high glucose concentration (16.7 mM)^[2].

体内研究
(In Vivo)

TUG-469 (5 mg/kg; i.p.; 60 and 90 min after glucose administration) affects blood glucose level^[2].

Animal Model:	Male NZO mice with glucose administration^[2]
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; 5 mg/kg; 60 and 90 min after glucose administration
Result:	Reduced the blood glucose level.

分子量

345.43

性状

Solid

Formula

C₂₃H₂₃NO₂

CAS 号

1236109-67-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL(289.49 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.8949 mL	14.4747 mL	28.9494 mL
5 mM	0.5790 mL	2.8949 mL	5.7899 mL
10 mM	0.2895 mL	1.4475 mL	2.8949 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。