CAS NO: | 925238-89-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with anIC50of 32 nM. | ||||||||||||||||
IC50& Target | IC50: 32 nM (GHS-R1a) | ||||||||||||||||
体外研究 (In Vitro) | JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50of 32 nM. JMV 2959 does not induce any intracellular calcium mobilization by itself[1]. | ||||||||||||||||
体内研究 (In Vivo) | When administered alone, it does not increase food intake and does not significantly stimulate growth hormone (GH) release[1]. JMV 2959 dose dependently decreases the startle response (F(3.42)=4.4, p<0.01) and increases %prepulse inhibition (PPI) (F(3.42)=3.9, p<0.05) in the prepulse inhibition paradigm. The alteration in the startle response is mainly due to a 27% decrease in the startle seen in the highest dose of JMV 2959 (6 mg/kg) compare to vehicle (p<0.05)[2]. 6 mg/kg JMV 2959 induces a significant suppression of locomotion on days 1 to 7 relative to baseline day 0 (F(7,49)=2.21, p<0.05). Results also reveal a significant interaction between JMV 2959 treatment and day (F(1,14)=4.397, p<0.05)[3]. | ||||||||||||||||
分子量 | 508.61 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C30H32N6O2 | ||||||||||||||||
CAS 号 | 925238-89-7 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 25 mg/mL(49.15 mM;ultrasonic and warming and heat to 60℃) 配制储备液
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