CAS NO: | 193273-69-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
2mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | Capromorelin Tartrate is an orally active, potentgrowth hormone secretagogue receptor (GHSR)agonist, withKiof 7 nM for hGHS-R1a. | ||||||||||||||||
IC50& Target | Ki: 7 nM (hGHS-R1a)[2] | ||||||||||||||||
体外研究 (In Vitro) | Capromorelin stimulates GH release in rat pituitary cell cultures with EC50of 3 nM[2]. | ||||||||||||||||
体内研究 (In Vivo) | Dogs receiving capromorelin (30 mg/mL) have food consumption that is significantly greater than dogs treated with placebo. All dogs in the capromorelin group gain weight by 0.52 kg, more than that of placebo group[1]. Capromorelin shows enhanced intestinal absorption in rodent models and exhibits superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)=65%, F(dog)=44%][2]. Capromorelin stimulates GH release in anesthesized rat model, with ED50of 0.05 mg/kg iv[2]. | ||||||||||||||||
分子量 | 655.70 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C32H41N5O10 | ||||||||||||||||
CAS 号 | 193273-69-7 | ||||||||||||||||
中文名称 | 卡普瑞林酒石酸盐 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 100 mg/mL(152.51 mM;Need ultrasonic) DMSO : 100 mg/mL(152.51 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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