CAS NO: | 1144477-35-9 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | TM-N1324 is an agonist of G-Protein-Coupled Receptor 39 (GPR39) withEC50s of 9 nM/5 nM in the presence of Zn2+, and 280 nM/180 nM in the absence of Zn2+forhuman/murine GPR39. | ||||||||||||||||
IC50& Target | EC50: 280 nM (human GPR39 without Zn2+), 9 nM (human GPR39 with Zn2+), 180 nM (murine GPR39 without Zn2+), 5 nM (murine GPR39 with Zn2+)[1] | ||||||||||||||||
体外研究 (In Vitro) | TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively. TM-N1324 has similar potencies on murine GPR39, 180 nM and 5 nM. TM-N1324 is also found to have promisingin vitroADME properties. TM-N1324 has reasonably good aqueous solubility (65 μM at pH 7.0). Measurements of somatostatin confirms that the GPR39 agonist TM-N1324 increases somatostatin release by 53%[1]. | ||||||||||||||||
分子量 | 397.79 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C18H13ClFN7O | ||||||||||||||||
CAS 号 | 1144477-35-9 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 12.22 mg/mL(30.72 mM;Need ultrasonic) 配制储备液
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