CAS NO: | 1640226-17-0 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
生物活性 | YIL781 hydrochloride is a potent and orally activeghrelin receptor (GHSR)antagonist. YIL781 hydrochloride produces a greater improvement in glucose homeostasis in rats. YIL-781 hydrochloride inhibits the calcium response induced by ghrelin with pIC50values of 7.90 and 8.27, respectively[1][2][3][4]. | ||||||||
体外研究 (In Vitro) | YIL-781 (10-300 nM) induces a concentration-dependent parallel rightward shift of the ghrelin CRC with a slight but statistically significant depression of the maximal response at 100 and 300 nM, reaching a similar agonist maximal response of approximately 90%[3]. | ||||||||
体内研究 (In Vivo) | YIL781 (0.1 to 5 μg/5 μl) attenuates ghrelin-induced up-regulation of the blood glucose level. The i.t. treatment with YIL781 alone does not affect the blood glucose level (F = 0.8160; P = 0.5095)[4].
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分子量 | 445.96 | ||||||||
性状 | Solid | ||||||||
Formula | C24H29ClFN3O2 | ||||||||
CAS 号 | 1640226-17-0 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |