Thiodigalactoside

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Thiodigalactoside

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

51555-87-4

包装与价格：

包装	价格(元)
10 mM * 1 mL in Water	电议
25mg	电议
50mg	电议
100mg	电议

产品名称

TDG

产品介绍

Thiodigalactoside (TDG) 是一种具有口服活性的，有效的半乳凝素 (GAL) 抑制剂，对于 GAL-1 和 GAL-3 的K_d值分别为 24 μM，49 μM。Thiodigalactoside 是一种不可代谢的二糖，具有抗炎和抗癌活性。Thiodigalactoside 可显着降低饮食诱发的肥胖大鼠的体重增加。

生物活性

Thiodigalactoside (TDG) is an orally active and potentgalectin(GAL)inhibitor withK_dvalues of 24 μM, 49 μM for GAL1 and GAL3, respectively^[1]. Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats^[2].

IC₅₀& Target

Kd: 24 μM (GAL1) and 49 μM (GAL3)^[1]

体外研究
(In Vitro)

Thiodigalactoside (TDG; 250 and 500 μM) exhibits dose-dependent reduction of fat accumulation based on triglyceride (TG) content and Oil Red O (ORO) staining^[1].

体内研究
(In Vivo)

Thiodigalactoside (TDG; 5 mg/kg; IP; once per week for 5 weeks) results in dramatic inhibition of HFD-induced body weight gain^[2].
Thiodigalactoside (5 mg/kg; oral; daily or weekly for 5 weeks) gave less reduction in body weight gain compare with i.p.^[2].

Animal Model:	Five-week-old Sprague-Dawley (SD) male rats^[2]
Dosage:	5 mg/kg
Administration:	IP; once per week for 5 weeks
Result:	Resulted in dramatic inhibition of HFD-induced body weight gain by inhibiting adipogenesis and lipogensis as well as by increasing expression of the proteins associated with thermogenesis and energy expenditure.

分子量

358.36

性状

Solid

Formula

C₁₂H₂₂O₁₀S

CAS 号

51555-87-4

中文名称

硫代半乳糖苷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 100 mg/mL(279.05 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.7905 mL	13.9525 mL	27.9049 mL
5 mM	0.5581 mL	2.7905 mL	5.5810 mL
10 mM	0.2790 mL	1.3952 mL	2.7905 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (279.05 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。