Glucocorticoid receptoragonist-2 (compound 21) is anglucocorticoid receptoragonist with anIC₅₀value of 6.6 nM.Glucocorticoid receptoragonist-2 can be used to synthesize anti-inflammatory ADC molecules.Glucocorticoid receptoragonist-2 is an active reference of ABBV-3373^[1].

Glucocorticoid receptor agonist-2 对糖皮质激素受体 (GR) 和孕激素受体 (PR) 结合的 IC₅₀值分别为 6.6 和 7.3 nM^[1]。
Glucocorticoid receptor agonist-2 对糖皮质激素效应元件 (GRE) 报告基因和盐皮质激素受体 (MR) 的 EC₅₀值分别为 0.2 和 442 nM^[1]。
Glucocorticoid receptor agonist-2 对盐皮质激素受体激动活性的 EC₅₀值为 149 nM^[1]。

607.64

Solid

C₃₄H₃₅F₂NO₇

2166378-92-1

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)