CAS NO: | 332437-00-0 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
生物活性 | ODN 2216 is aTLR9(toll-like receptor 9) ligand or agonist. ODN 2216 induces high amounts ofIFN-αandIFN-β. ODN 2216 induces IFN-α by pDC (plasmacytoid DC) andIL-12(p40)production by DC (dendritic cells). ODN 2216 stimulatesIFN-γproduction in peripheral blood mononuclear cells (PBMC), which is indirect and mediated by IFN-α/β. ODN 2216 can activate NK cells and promoteIFN-γproduction of TCR-triggeredCD4+T cells[1][2][3][4]. | ||||||||
IC50& Target |
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体外研究 (In Vitro) | ODN 2216 (6 μg/mL, 9 days) drives Th1 development of naive CD4 T cells[1]. Apoptosis Analysis[2]
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体内研究 (In Vivo) | ODN 2216 induces T-cell mediated antitumor immune response in murine vaccination models[3] | ||||||||
分子量 | 6432.00 | ||||||||
性状 | Solid | ||||||||
CAS 号 | 332437-00-0 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |