Pim-1 kinase inhibitor 1

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CAS NO:

2803505-57-7

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Pim-1 kinase inhibitor 1 是Pim-1的激酶抑制剂，其IC₅₀值为 0.11 μM。Pim-1 kinase inhibitor 1 通过促进细胞凋亡对多种癌细胞显示出抗癌活性。Pim-1 kinase inhibitor 1 可用于癌症的研究。

生物活性

Pim-1 kinase inhibitor 1 is aPim-1kinase inhibitor with anIC₅₀of 0.11 μM for Pim-1 kinase. Pim-1 kinase inhibitor 1 shows anticancer activity to severalcancercell lines by promotes cellapoptosis. Pim-1 kinase inhibitor 1 can be used for the research ofcancer^[1].

IC₅₀& Target

IC50: 0.11 μM (Pim-1 kinase), 10.93 μM (MCF-7), 4.91 μM (CACO), 7.01 μM (HepG-2), 3.41 μM (HCT-116), 27.181 μM (WI-38)^[1]

体外研究
(In Vitro)

Pim-1 kinase inhibitor 1 (0-200 μM; 24 h) shows vitro cytotoxic activity to several cancer cells and affects cell apoptosis^[1].

Cell Cytotoxicity Assay^[1]

Cell Line:	MCF-7, CACO, HepG-2, HCT-116 and WI-38 cells
Concentration:	0-200 μM
Incubation Time:	24 hours
Result:	Exhibited vitro cytotoxic activity to MCF-7, CACO, HepG-2, HCT-116 and WI-38 cell lines with IC₅₀s of 10.93, 4.91, 7.01, 3.41 and 27.181 μM, respectively. Promoted apoptosis by increasing Casp-3, BAX and Bcl-2 concentration to achieve anti-cancer activity.

分子量

331.32

Formula

C₁₉H₁₃N₃O₃

CAS 号

2803505-57-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.