CAS NO: | 2093393-05-4 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | TC13172 is amixed lineage kinasedomain-like protein (MLKL) inhibitor with anEC50value of 2 nM for HT-29 cells[1]. | ||||||||||||||||
IC50& Target | EC50: 2±0.6 nM (MLKL, in HT-29 cells)[1]. | ||||||||||||||||
体外研究 (In Vitro) | The anti-necroptosis potency of TC13172 is evaluated in the HT-29 cell line, the EC50value is 2±0.6 nM. TC13172 has an inhibition potency of 2 nM against cell necroptosis. TC13172 inhibits MLKL by directly binding to Cys-86. TC13172 does not disrupt the phosphorylation of MLKL, but do decrease the level of MLKL in the membrane phase, demonstrating that these MLKL inhibitors block the translocation of MLKL to the cell membrane, thereby protecting cells from necroptosis[1]. | ||||||||||||||||
分子量 | 388.40 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C17H16N4O5S | ||||||||||||||||
CAS 号 | 2093393-05-4 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 25 mg/mL(64.37 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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