Necrosulfonamide-d4 is the deuterium labeled Necrosulfonamide. Necrosulfonamide is anecroptosisinhibitor acting by selectively targeting themixed lineage kinasedomain-like protein(MLKL). Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. MLKL is a critical substrate of RIP3 during the induction of necrosis^[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

465.50

C₁₈H₁₁D₄N₅O₆S₂

1795144-22-7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.