您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > MNK1/2-IN-6
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
MNK1/2-IN-6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MNK1/2-IN-6图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
MNK1/2-IN-6 是一种有效的选择性的MNK1/2抑制剂,IC50s 分别为 2.3 nM 和 3.4 nM。 MNK1/2-IN-6 以浓度依赖性方式诱导细胞凋亡apoptosis
生物活性

MNK1/2-IN-6 is a potent and selectiveMNK1/2inhibitor withIC50s of 2.3 nM and 3.4 nM forMNK1andMNK2, respectively. MNK1/2-IN-6 inducesapoptosisin a concentration-dependent manner[1].

IC50& Target[1]

MNK1

2.3 nM (IC50)

MNK2

3.4 nM (IC50)

体外研究
(In Vitro)

MNK1/2-IN-6 (compound II-5) (72 h) shows antiproliferative activity with IC50s of 0.3896μM, 0.4092 μM for TMD-8, DOHH-2 cells, respectively[1].
MNK1/2-IN-6 (0.25, 0.5, 1 μM; 24 h) induces TMD-8 cells apoptosis in a concentration-dependent manner[1].

Cell Proliferation Assay[1]

Cell Line:TMD-8, DOHH-2 cells
Concentration:
Incubation Time:72 h
Result:Showed antiproliferative activity with IC50s of 0.39μM, 0.41 μM for TMD-8, DOHH-2 cells, respectively.

Apoptosis Analysis[1]

Cell Line:TMD-8 cells
Concentration:0.25, 0.5, 1 μM
Incubation Time:24 h
Result:Induced TMD-8 cells apoptosis in a concentration-dependent manner.
分子量

448.52

Formula

C27H24N6O

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.