CAS NO: | 1469988-63-3 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | QL-X-138 is a potent and selectiveBTK/MNK dual kinaseinhibitor, exhibits covalent binding toBTKand non-covalent binding toMNK. QL-X-138 showsIC50s of 9.4 nM, 107.4 nM and 26 nM forBTK,MNK1andMNK2kinases respectively. QL-X-138 also shows anti-dengue virus 2activity, with anIC50of 3.5 μM. QL-X-138 can be used for the research of B-cell malignancies[1][2]. | ||||||||
体外研究 (In Vitro) | QL-X-138 (72 h) exhibits anti-proliferation activity against lymphoma and leukemia cell lines, with an GI50s of 0.31, 1.2, 0.49,1.4, 0.4, 0.23, 0.95, 1.2, 1.4, 0.23, 1.3, 0.93, 1, and 2.4 μM for TMD8, U2932, Ramos, OCI-AML3, SKM-1, NOMO-1, NB4, HEL, U937, NALM6, MEC-1, MEC-2, Hs 505.T and REC-1 cells, respectively[1]. Western Blot Analysis[1]
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分子量 | 421.45 | ||||||||
Formula | C25H19N5O2 | ||||||||
CAS 号 | 1469988-63-3 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |