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JNJ-49095397
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JNJ-49095397图片
CAS NO:1220626-82-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
RV568
产品介绍
JNJ-49095397 (RV568) 是一种吸入性窄谱激酶抑制剂 (NSKI),可抑制p38 MAPK的 α 和 γ 亚型。JNJ-49095397 还抑制SRC kinase家族,特别是造血激酶(HCK),显示出强大的抗炎作用,可用于慢性阻塞性肺疾病 (COPD) 和哮喘的研究。
生物活性

JNJ-49095397 (RV568) is an inhaled narrow-spectrum kinase inhibitor (NSKI) against both the α and γ isoforms ofp38 MAPK. JNJ-49095397 also inhibitsSRCkinasefamily, specifically haematopoietic kinase (HCK) JNJ-49095397 shows potent anti-inflammatory effects and can be used for the research of chronic obstructive pulmonary disease (COPD) and asthma[1].

IC50& Target[1]

p38α

 

p38γ

 

Haematopoietic Kinase (HCK)

 

体外研究
(In Vitro)

JNJ-49095397 (RV568) (1 pg-1 μg/mL;4 h) 在 PBMCs 和 d-U937 细胞中抑制 LPS 诱导的 CXCL8 释放[1]
JNJ-49095397 (1 μg-1 g/mL; 4 h) 以浓度依赖的方式抑制 TNFα 诱导的白细胞介素 (IL)-6 和 CXCL8 的释放[1]

体内研究
(In Vivo)

JNJ-49095397 (RV568) (1-20 μg/mouse; intratracheal; once) 在 LPS 诱导的中性粒细胞积累小鼠模型中显示出抗炎活性[1]

Animal Model:Nonfasted Balb/c mice, LPS-induced neutrophil accumulation model[1]
Dosage:1, 4 and 20 μg/mouse
Administration:Intratracheal administration, 2, 8 or 12 h prior to LPS inhalation
Result:Prevented the accumulation of neutrophils in the BAL fluid. Significantly inhibited neutrophil accumulation when administered up to 8 h prior to LPS inhalation.
分子量

592.69

Formula

C34H36N6O4

CAS 号

1220626-82-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.