CAS NO: | 918504-65-1 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
10 g | 电议 |
生物活性 | Vemurafenib (PLX4032) is a first-in-class, selective, potent inhibitor ofB-RAFkinase, withIC50s of 31 and 48 nM forRAFV600Eand c-RAF-1, respectively[1][4]. Vemurafenib induces cellautophagy[5]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Vemurafenib (PLX4032) selectively blocks the RAF/MEK/ERK pathway in BRAF mutant cells[1]. RG7204 is a potent inhibitor of proliferation in those expressing RAFV600Ebut not BRAFWTin 17 melanoma cell lines. Vemurafenib (RG7204) induces MEK and ERK phosphorylation at high concentrations in CHL-1 cells[2]. Ectopic expression of EGFR in melanoma cells is sufficient to cause resistance to PLX4032[3]. | ||||||||||||||||
体内研究 (In Vivo) | Vemurafenib (PLX4032, 20, 25, 75 mg/kg, p.o.) causes dose-dependent inhibition of tumor growth, with higher exposures resulting in tumor regression of BRAF mutant xenografts[1]. RG7204 (12.5, 25, and 75 mg/kg, p.o.) significantly inhibits tumor growth and induced tumor regression in mice bearing LOX tumor xenografts[2]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 489.92 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C23H18ClF2N3O3S | ||||||||||||||||
CAS 号 | 918504-65-1 | ||||||||||||||||
中文名称 | 维罗非尼;维罗菲尼;威罗菲尼;唯罗非尼 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 50 mg/mL(102.06 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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